Article
Ig beta deficiency in humans.
Current opinion in allergy and clinical immunology - 1 Dec 2008
Lougaris Vassilios, Ferrari Simona, Plebani Alessandro
Abstract excerpt
PURPOSE OF REVIEW: To describe novel immunological and molecular findings regarding early B cell development arrest resulting in autosomal recessive agammaglobulinemia. RECENT FINDINGS: Recently two different groups identified mutations in Ig beta, a component of the pre-B cell receptor, responsible for agammaglobulinemia in humans. These are the first two patients ever described with mutations in Ig beta....
Topics
- Agammaglobulinemia
- Animals
- B-Lymphocyte Subsets
- B-Lymphocytes
- CD79 Antigens
- DNA Mutational Analysis
- Genes, Recessive
- Genetic Therapy
- Humans
- Mice
- Mice, Knockout
- Mutation