Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular analysis of the pre-BCR complex in a large cohort of patients affected by autosomal-recessive agammaglobulinemia.

Genes and immunity - 1 Jun 2007

Ferrari S, Zuntini R, Lougaris V, Soresina A, Sourková V, Fiorini M, Martino S, Rossi P, Pietrogrande M C, Martire B, Spadaro G, Cardinale F, Cossu F, Pierani P, Quinti I, Rossi C, Plebani A

Abstract excerpt

Autosomal-recessive agammaglobulinemia is a rare and heterogeneous disorder, characterized by early-onset infections, profound hypogammaglobulinemia of all immunoglobulin isotypes and absence of circulating B lymphocytes. To investigate the molecular basis of the disease, 23 patients with early-onset disease and no mutations in Bruton tyrosine kinase, the gene responsible for X-linked agammaglobulinemia, were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agammaglobulinaemia Tyrosine Kinase
Share to Agammaglobulinemia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to B-Lymphocytes

Share to Genes, Immunoglobulin

Share to Immunoglobulin Light Chains

Share to Immunoglobulin mu-Chains

Share to Protein-Tyrosine Kinases

Share to Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 17410177
DOI: 10.1038/sj.gene.6364391

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular analysis of the pre-BCR complex in a large cohort of patients affected by autosomal-recessive agammaglobulinemia.PMID 17410177Read ↗

Autosomal recessive agammaglobulinemia: novel insights from mutations in Ig-beta.Semantic proximity Read ↗

Clinical and molecular analysis of patients with defects in μ heavy chain geneSemantic proximity Read ↗

Autosomal recessive agammaglobulinemia due to compound heterozygous IGHM alterations identified: a case reportSemantic proximity Read ↗

Agammaglobulinemia: causative mutations and their implications for novel therapies.Semantic proximity Read ↗

A new case of autosomal recessive agammaglobulinaemia with impaired pre-B cell differentiation due to a large deletion of the IGH locus.Semantic proximity Read ↗

Genetic Approaches for Definitive Diagnosis of Agammaglobulinemia in Consanguineous Families.Semantic proximity Read ↗

Clinical, immunological and genomic characteristics of children with X-linked agammaglobulinemia from Kerala, South India.Semantic proximity Read ↗

Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway.Semantic proximity Read ↗

Clinical features and mutational analysis of X-linked agammaglobulinemia patients in MalaysiaSemantic proximity Read ↗

Autosomal recessive agammaglobulinemic patient with a novel large deletion in IGHM presenting with mild clinical phenotype.Semantic proximity Read ↗

Mutations in the mu heavy-chain gene in patients with agammaglobulinemia.Semantic proximity Read ↗

Recurrent pneumonia with mild hypogammaglobulinemia diagnosed as X-linked agammaglobulinemia in adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.