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Article

A cholera toxin B-subunit variant that binds ganglioside G(M1) but fails to induce toxicity.

The Journal of biological chemistry - 5 Oct 2001

Rodighiero C, Fujinaga Y, Hirst T R, Lencer W I

Abstract excerpt

Entry of cholera toxin (CT) into target epithelial cells and the induction of toxicity depend on CT binding to the lipid-based receptor ganglioside G(M1) and association with detergent-insoluble membrane microdomains, a function of the toxin's B-subunit. The B-subunits of CT and related Escherichia coli toxins exhibit a highly conserved exposed peptide loop (Glu(51)-Ile(58)) that faces the cell membrane upon...

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PMID: 11479294
DOI: 10.1074/jbc.M104245200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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