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Article

Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells.

The Biochemical journal - 1 Jul 2008

Dayal Disha, Martin Sean M, Limoli Charles L, Spitz Douglas R

Abstract excerpt

Chronic oxidative stress has been associated with genomic instability following exposure to ionizing radiation. However, results showing direct causal linkages between specific ROS (reactive oxygen species) and the ionizing radiation-induced mutator phenotype are lacking. The present study demonstrates that ionizing radiation-induced genomically unstable cells (characterized by chromosomal instability and an...

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Identifiers

PMID: 18352860
DOI: 10.1042/BJ20071643
PMCID: PMC2677991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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