Article
A radioresistant variant derived from a human neuroblastoma cell line is less prone to radiation-induced apoptosis.
Cancer research - 1 Nov 1995
Russell J, Wheldon T E, Stanton P
Abstract excerpt
By subjecting radiosensitive human neuroblastoma IMR 32 cells to a regime of fractionated X-irradiation, a radioresistant variant, XRIMR 32, was obtained. Radiation resistance of XRIMR 32 cells was demonstrated by clonogenic and spheroid regrowth delay assays. The XRIMR 32 cultures were phenotypi...
Topics
- Apoptosis
- Base Sequence
- Cell Cycle
- Cell Division
- DNA Damage
- DNA Repair
- DNA, Neoplasm
- Genetic Variation
- Humans
- Micronuclei, Chromosome-Defective
- Molecular Sequence Data
- Neoplasm Staging
- Neuroblastoma
- Radiation Tolerance
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53
- X-Rays