Article
A role for genomic instability in cellular radioresistance?
Cancer metastasis reviews - 1 Mar 1995
Morgan W F, Murnane J P
Abstract excerpt
Inherent cellular radioresistance plays a critical role in the failure of radiotherapy. Although the consequences of radioresistance are well known, the molecular, biological, and cellular bases of radioresistance remain a mystery. We propose that genomic instability, the increased rate of acquisition of alterations in the mammalian genome, can directly modulate cells' sensitivity to radiation. In particular,...
Topics
- Animals
- Cell Cycle
- Cell Survival
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- DNA Damage
- DNA Repair
- Gene Expression Regulation, Neoplastic
- Genome
- Genome, Human
- Humans
- Mutation