Article
Genomic instability and metastatic progression.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1993
Usmani B A
Abstract excerpt
Recently, there has been a growing body of opinion that tumour cells progress from a less malignant to a more malignant (metastatic) phenotype, due to an inherent instability within the genome. It has also been suggested that genomic instability and the rate of generation of metastatic variants both increase as the tumour cells achieve a higher state of malignancy. In this review, several different aspects of...
Topics
- Animals
- DNA Damage
- DNA Repair
- Gene Amplification
- Genetic Variation
- Humans
- Mutation
- Neoplasm Metastasis
- Neoplasms
- Neoplasms, Experimental
- Phenotype
- Recombination, Genetic