Article
The cellular response to PPARgamma ligands is related to the phenotype of neuroblastoma cell lines.
Oncology research - 1 Jan 2004
Servidei Tiziana, Morosetti Roberta, Ferlini Cristiano, Cusano Gabriella, Scambia Giovanni, Mastrangelo Renato, Koeffler H Phillip
Abstract excerpt
Neuroblastoma (NB) is a phenotypically heterogeneous tumor, displaying cells of neuronal, melanocytic, or glial/schwannian lineage. This cellular heterogeneity is also present in vitro, where cells of neuroblastic (N)- or stromal (S)-type may be identified. Ligands of peroxisome proliferator-activated receptor gamma (PPARgamma) have been shown to inhibit growth in different tumor cell lines. The purpose of this...
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