Article
Expression of a carboxy-terminal region of the beta-amyloid precursor protein in a heterogeneous culture of neuroblastoma cells: evidence for altered processing and selective neurotoxicity.
Brain research. Molecular brain research - 1 Nov 1992
Fukuchi K, Kamino K, Deeb S S, Furlong C E, Sundstrom J A, Smith A C, Martin G M
Abstract excerpt
Six independent clonal isolates from a morphologically heterogeneous human neuroblastoma cell line stably expressed several products of the human amyloid precursor protein (APP) from an introduced DNA construct; the "substrate-adherent" phenotype (fibroblast-like cells) predominated in all 6; these displayed immunoreactivity of vimentin, but little to no reactivity of neuron-specific enolase. A stably transfected...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.