Expression of a carboxy-terminal region of the beta-amyloid precursor protein in a heterogeneous culture of neuroblastoma cells: evidence for altered processing and selective neurotoxicity.

doi:10.1016/0169-328x(92)90191-d

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Article

Expression of a carboxy-terminal region of the beta-amyloid precursor protein in a heterogeneous culture of neuroblastoma cells: evidence for altered processing and selective neurotoxicity.

Brain research. Molecular brain research - 1 Nov 1992

Fukuchi K, Kamino K, Deeb S S, Furlong C E, Sundstrom J A, Smith A C, Martin G M

Abstract excerpt

Six independent clonal isolates from a morphologically heterogeneous human neuroblastoma cell line stably expressed several products of the human amyloid precursor protein (APP) from an introduced DNA construct; the "substrate-adherent" phenotype (fibroblast-like cells) predominated in all 6; these displayed immunoreactivity of vimentin, but little to no reactivity of neuron-specific enolase. A stably transfected...

Topics

Amyloid beta-Protein Precursor
Animals
Cell Differentiation
Cell Division
Cell Line
Culture Media, Conditioned
Genetic Markers
Genetic Vectors
Humans
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuroblastoma

Neurons

Phenotype

RNA, Messenger

Transfection

Tumor Cells, Cultured

Source

Open in PubMed

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PMID: 1334198
DOI: 10.1016/0169-328x(92)90191-d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1334198-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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