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Article

Genes from Chagas susceptibility loci that are differentially expressed in T. cruzi-resistant mice are candidates accounting for impaired immunity.

PloS one - 20 Dec 2006

Graefe Sebastian E B, Streichert Thomas, Budde Birgit S, Nürnberg Peter, Steeg Christiane, Müller-Myhsok Bertram, Fleischer Bernhard

Abstract excerpt

Variation between inbred mice of susceptibility to experimental Trypanosoma cruzi infection has frequently been described, but the immunogenetic background is poorly understood. The outcross of the susceptible parental mouse strains C57BL/6 (B6) and DBA/2 (D2), B6D2F1 (F1) mice, is highly resistant to this parasite. In the present study we show by quantitative PCR that the increase of tissue parasitism during the...

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PMID: 17183687
DOI: 10.1371/journal.pone.0000057
PMCID: PMC1762350

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