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Article

Genetic control of resistance to Trypanosoma brucei brucei infection in mice.

PLoS neglected tropical diseases - 1 Jun 2011

Síma Matyáš, Havelková Helena, Quan Lei, Svobodová Milena, Jarošíková Taťána, Vojtíšková Jarmila, Stassen Alphons P M, Demant Peter, Lipoldová Marie

Abstract excerpt

BACKGROUND: Trypanosoma brucei brucei infects livestock, with severe effects in horses and dogs. Mouse strains differ greatly in susceptibility to this parasite. However, no genes controlling these differences were mapped. METHODS: We studied the genetic control of survival after T. b. brucei infection using recombinant congenic (RC) strains, which have a high mapping power. Each RC strain of BALB/c-c-STS/A...

Topics

Animals
Chromosome Mapping
Crosses, Genetic
Female
Genetic Loci
Genotype
Immunity, Innate
Male
Mice
Mice, Inbred BALB C
Rodent Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Survival Analysis

Trypanosoma brucei brucei

Trypanosomiasis, African

Source

Open in PubMed Open full text

Identifiers

PMID: 21666791
DOI: 10.1371/journal.pntd.0001173
PMCID: PMC3110168

Genes

STS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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