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Article

Alzheimer's disease: a dysfunction of the amyloid precursor protein(1).

Brain research - 15 Dec 2000

Neve R L, McPhie D L, Chen Y

Abstract excerpt

In this review, we argue that at least one insult that causes Alzheimer's disease (AD) is disruption of the normal function of the amyloid precursor protein (APP). Familial Alzheimer's disease (FAD) mutations in APP cause a disease phenotype that is identical (with the exception that they cause an earlier onset of the disease) to that of 'sporadic' AD. This suggests that there are molecular pathways common to FAD...

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Source

Identifiers

PMID: 11119687
DOI: 10.1016/s0006-8993(00)02869-9

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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