Relationship between high incidence of adverse dapsone reactions and slow acetylate phenotype or low plasma/lymphocyte glutathione level.

Abstract excerpt

OBJECTIVE: To investigate the relationship between high incidence of adverse dapsone reactions in acquired immunodeficiency syndrome (AIDS) patients and slow acetylate phenotype or low plasma/lymphocyte glutathione level of these patients. METHODS: Twenty-one cases of advanced AIDS patients (CD4 < 200/microliter) were involved in this study, all Europeans except one black, were acetylate phenotyped via analysis...

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