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Article

Mutations of the C-terminal end of cathepsin K affect proenzyme secretion and intracellular maturation.

Biochemical and biophysical research communications - 23 Feb 2001

Claveau D, Riendeau D

Abstract excerpt

Transfection of the human cathepsin K cDNA into CHO cells results in the expression of mature catalytically active 27-kDa protein and in cells secreting the 39-kDa proenzyme form. Monensin, which neutralizes the pH of acidic organelles, was found to inhibit intracellular processing of the proenzyme and to stimulate its secretion into the culture medium. Brefeldin A caused alterations in immunofluorescence...

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Identifiers

PMID: 11181082
DOI: 10.1006/bbrc.2001.4394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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