Intracellular targeting of lysosomal cathepsin D in COS cells.

doi:10.1093/jb/118.5.981

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Article

Intracellular targeting of lysosomal cathepsin D in COS cells.

Journal of biochemistry - 1 Nov 1995

Takeshima H, Sakaguchi M, Mihara K, Murakami K, Omura T

Abstract excerpt

Cathepsin D carries a mannose 6-phosphate sorting signal which is recognized by a specific mannose 6-phosphate receptor, presumably at the site of the trans Golgi network, which segregates cathepsin D from the secretory proteins, and results in targeting of the enzyme to the acidic prelysosomal c...

Topics

Amino Acid Sequence
Animals
Cathepsin D
Cell Fractionation
Cell Line
DNA, Complementary
Evaluation Studies as Topic
Fluorescent Antibody Technique, Indirect
Gene Deletion
Glycosylation
Lysosomes
Molecular Sequence Data
Mutation
Protein Sorting Signals
Recombinant Proteins
Subcellular Fractions

Source

Open in PubMed

Identifiers

PMID: 8749316
DOI: 10.1093/jb/118.5.981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8749316-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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