Article

Intracellular trafficking and regulation of variant B cystatin C in retinal pigment epithelial cells

2017-01-01

Abstract excerpt

Cystatin C is an important inhibitor of lysosomal and extracellular cysteine proteases. It is synthesized as a precursor containing a signal sequence that targets the protein to the secretory pathway. In retinal pigment epithelial (RPE) cells, cystatin C is abundantly expressed and secreted, suggesting a critical role in the regulation of the proteolytic activity in the extracellular space, which, if altered, may...

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Literature Corpus work: 8d5656c2-d93f-5d46-8927-56b64fd0d34f
DOI: 10.17638/03005966

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