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Article

All post-translational modifications except propeptide cleavage are required for optimal secretion of coagulation factor VII.

Thrombosis and haemostasis - 1 Nov 2007

Bolt Gert, Steenstrup Thomas D, Kristensen Claus

Abstract excerpt

Human coagulation factor VII (FVII) has two N-glycosylation sites (N145 and N322) and two O-glycosylation sites (S52 and S60). In transiently transfected COS-7 cells, all combinations of N- and O-glycosylation knock-out mutations reduced the release of FVII to the medium. Pulse-chase analysis of CHO-K1 cell lines expressing recombinant FVII demonstrated that virtually all wild-type FVII synthesized was secreted...

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Identifiers

PMID: 18000603
DOI: 10.1160/th07-05-0332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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