Article
Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells.
The Journal of biological chemistry - 21 Oct 2011
Jemel Ikram, Ii Hiromi, Oslund Rob C, Payré Christine, Dabert-Gay Anne-Sophie, Douguet Dominique, Chargui Khaoula, Scarzello Sabine, Gelb Michael H, Lambeau Gérard
Abstract excerpt
Among mammalian secreted phospholipases A(2) (sPLA(2)s), group X sPLA(2) has the most potent hydrolyzing activity toward phosphatidylcholine and is involved in arachidonic acid (AA) release. Group X sPLA(2) is produced as a proenzyme and contains a short propeptide of 11 amino acids ending with a dibasic motif, suggesting cleavage by proprotein convertases. Although the removal of this propeptide is clearly...
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