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Article

Transport of meprin subunits through the secretory pathway: role of the transmembrane and cytoplasmic domains and oligomerization.

The Journal of biological chemistry - 13 Aug 2004

Hengst Jeremy A, Bond Judith S

Abstract excerpt

The meprin alpha subunit, a multidomain metalloproteinase, is synthesized as a type I membrane protein and proteolytically cleaved during biosynthesis in the endoplasmic reticulum (ER), consequently losing its membrane attachment and COOH-terminal domains. The meprin alpha subunit is secreted as a disulfide-linked dimer that forms higher oligomers. By contrast, the evolutionarily related meprin beta subunit...

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PMID: 15187079
DOI: 10.1074/jbc.M405774200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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