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Article

Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis.

The EMBO journal - 17 May 1999

Lock M, Greenberg M E, Iafrate A J, Swigut T, Muench J, Kirchhoff F, Shohdy N, Skowronski J

Abstract excerpt

The simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) Nef proteins induce the endocytosis of CD4 and class I MHC molecules. Here we show that SIV Nef interacts with the AP-2 adaptor complex via two elements located in the N-terminal region of the Nef molecule, bu...

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Share to Adaptor Proteins, Vesicular Transport
Share to CD4 Antigens
Share to Clathrin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endocytosis

Share to Gene Products, nef

Share to Jurkat Cells

Share to nef Gene Products, Human Immunodeficiency Virus

Share to Simian Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 10329619
DOI: 10.1093/emboj/18.10.2722
PMCID: PMC1171354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10329619-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis.PMID 10329619Read ↗

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