Article
Expression of cytolethal distending toxin and hemolysin is not required for pustule formation by Haemophilus ducreyi in human volunteers.
Infection and immunity - 1 Mar 2001
Young R S, Fortney K R, Gelfanova V, Phillips C L, Katz B P, Hood A F, Latimer J L, Munson R S, Hansen E J, Spinola S M
Abstract excerpt
Haemophilus ducreyi makes cytolethal distending toxin (CDT) and hemolysin. In a previous human challenge trial, an isogenic hemolysin-deficient mutant caused pustules with a rate similar to that of its parent. To test whether CDT was required for pustule formation, six human subjects were inoculated with a CDT mutant and parent at multiple sites. The pustule formation rates were similar at both parent and mutant...
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