Article
Inactivation of the Haemophilus ducreyi luxS gene affects the virulence of this pathogen in human subjects.
The Journal of infectious diseases - 1 Aug 2009
Labandeira-Rey Maria, Janowicz Diane M, Blick Robert J, Fortney Kate R, Zwickl Beth, Katz Barry P, Spinola Stanley M, Hansen Eric J
Abstract excerpt
Haemophilus ducreyi 35000HP contains a homologue of the luxS gene, which encodes an enzyme that synthesizes autoinducer 2 (AI-2) in other gram-negative bacteria. H. ducreyi 35000HP produced AI-2 that functioned in a Vibrio harveyi-based reporter system. A H. ducreyi luxS mutant was constructed by insertional inactivation of the luxS gene and lost the ability to produce AI-2. Provision of the H. ducreyi luxS gene...
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