Article
Evaluation of an isogenic hemolysin-deficient mutant in the human model of Haemophilus ducreyi infection.
The Journal of infectious diseases - 1 Jul 1998
Palmer K L, Thornton A C, Fortney K R, Hood A F, Munson R S, Spinola S M
Abstract excerpt
Haemophilus ducreyi causes the genital ulcerative disease chancroid. One putative virulence factor of H. ducreyi is a pore-forming hemolysin that displays toxicity against human fibroblasts and keratinocytes. In order to test the role of the hemolysin in pathogenesis, an isogenic hemolysin-defici...
Topics
- Adult
- Chancroid
- Double-Blind Method
- Female
- Haemophilus ducreyi
- Hemolysin Proteins
- Humans
- Male
- Mutagenesis
- Phenotype
- Virulence