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Article

Haemophilus ducreyi lipooligosaccharide mutant defective in expression of beta-1,4-glucosyltransferase is virulent in humans.

Infection and immunity - 1 Jun 2001

Young R S, Filiatrault M J, Fortney K R, Hood A F, Katz B P, Munson R S, Campagnari A A, Spinola S M

Abstract excerpt

The lipooligosaccharide (LOS) of Haemophilus ducreyi contains a major glycoform that is immunochemically identical to paragloboside, a glycosphingolipid precursor of major human blood group antigens. We recently identified the gene responsible for the glucosyltransferase activity and constructed an isogenic mutant (35000glu-) deficient in this activity. 35000glu- makes an LOS that consists only of the heptose...

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Identifiers

PMID: 11349097
DOI: 10.1128/IAI.69.6.4180-4184.2001
PMCID: PMC98490

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