Article
A superoxide dismutase C mutant of Haemophilus ducreyi is virulent in human volunteers.
Infection and immunity - 1 Mar 2002
Bong Cliffton T H, Fortney Kate R, Katz Barry P, Hood Antoinette F, San Mateo Lani R, Kawula Thomas H, Spinola Stanley M
Abstract excerpt
Haemophilus ducreyi produces a periplasmic copper-zinc superoxide dismutase (Cu-Zn SOD), which is thought to protect the organism from exogenous reactive oxygen species generated by neutrophils during an inflammatory response. We had previously identified the gene, sodC, responsible for the production and secretion of Cu-Zn SOD and constructed an isogenic H. ducreyi strain with a mutation in the sodC gene...
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