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Article

Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43.

Circulation - 2 Mar 2004

van Rijen Harold V M, Eckardt Dominik, Degen Joachim, Theis Martin, Ott Thomas, Willecke Klaus, Jongsma Habo J, Opthof Tobias, de Bakker Jacques M T

Abstract excerpt

BACKGROUND: Connexin 43 (Cx43) is a major determinant of conduction in the ventricular working myocardium of mammals. We investigated the effect of decreased Cx43 expression on conduction velocity and arrhythmogenesis using adult mice with inducible deletion of Cx43. METHODS AND RESULTS: Cx43Cre-...

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Identifiers

PMID: 14967725
DOI: 10.1161/01.CIR.0000117402.70689.75

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14967725-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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