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Cardiac Electrophysiology in Genetically Engineered Mice

1 Mar 2000

Abstract excerpt

The mouse has become the principal animal model for studying biologic processes in mammals. Major advances in transgene and gene targeting technology enabled manipulation of the mouse genome in a predictable fashion. Mutant mouse strains provide important insights into the molecular mechanisms underlying normal and disordered cardiac conduction and sudden cardiac death. A variety of mouse strains harboring gene...

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PMID: 10749360
DOI: 10.1111/j.1540-8167.2000.tb01806.x

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