Article
Heterogeneous expression of Gap junction channels in the heart leads to conduction defects and ventricular dysfunction.
Circulation - 4 Sept 2001
Gutstein D E, Morley G E, Vaidya D, Liu F, Chen F L, Stuhlmann H, Fishman G I
Abstract excerpt
BACKGROUND: - Heterogeneous remodeling of gap junctions is observed in many forms of heart disease. The consequent loss of synchronous ventricular activation has been hypothesized to result in diminished cardiac performance. To directly test this hypothesis, we designed a murine model of heteroge...
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