Article
Clonal expansions of mitochondrial genomes: implications for in vivo mutational spectra.
Mutation research - 28 Jan 2003
Khrapko Konstantin, Nekhaeva Ekaterina, Kraytsberg Yevgenya, Kunz Wolfram
Abstract excerpt
It is often assumed mutant frequencies, as measured in a DNA sample, faithfully represent basic mutation rates associated with these mutations. This paradigm was extremely helpful for in vitro studies of the mechanisms of mutagenesis/repair and causes of mutations. However, in vivo, mutant fractions appear to vary dramatically and randomly from sample to sample. It's unlikely that basic mutational rates vary so...
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