Article
Mutation and intracellular clonal expansion of mitochondrial genomes: two synergistic components of the aging process?
Mechanisms of ageing and development - 1 Jan 2003
Kraytsberg Yevgenya, Nekhaeva Ekaterina, Bodyak Natalya B, Khrapko Konstantin
Abstract excerpt
The foundations of the Mitochondrial mutational theory of aging include two assumptions: the high abundance of mitochondrial mutations and their ability to clonally expand within individual cells. The up-to-date data pertinent to these assumptions is reviewed and semi-quantitative estimates of the frequencies of mutants and intracellular expansions are offered. The incidence of mutations in various aged tissues...
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