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Article

Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function.

The EMBO journal - 5 May 2010

Manford Andrew, Xia Tian, Saxena Ajay Kumar, Stefan Christopher, Hu Fenghua, Emr Scott D, Mao Yuxin

Abstract excerpt

Sac family phosphoinositide (PI) phosphatases are an essential family of CX(5)R(T/S)-based enzymes, involved in numerous aspects of cellular function such as PI homeostasis, cellular signalling, and membrane trafficking. Genetic deletions of several Sac family members result in lethality in animal models and mutations of the Sac3 gene have been found in human hereditary diseases. In this study, we report the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20389282
DOI: 10.1038/emboj.2010.57
PMCID: PMC2876947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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