Article
SR protein kinase 1 is resilient to inactivation.
Structure (London, England : 1993) - 1 Jan 2007
Ngo Jacky Chi Ki, Gullingsrud Justin, Giang Kayla, Yeh Melinda Jean, Fu Xiang-Dong, Adams Joseph A, McCammon J Andrew, Ghosh Gourisankar
Abstract excerpt
SR protein kinase 1 (SRPK1) is a constitutively active kinase, which processively phosphorylates multiple serines within its substrates, ASF/SF2. We describe crystallographic, molecular dynamics, and biochemical results that shed light on how SRPK1 preserves its constitutive active conformation. Our structure reveals that unlike other known active kinase structures, the activation loop remains in an active state...
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