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Article

The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.

PLoS genetics - 1 Aug 2018

Kyrchanova Olga, Kurbidaeva Amina, Sabirov Marat, Postika Nikolay, Wolle Daniel, Aoki Tsutomu, Maksimenko Oksana, Mogila Vladic, Schedl Paul, Georgiev Pavel

Abstract excerpt

Expression of the three bithorax complex homeotic genes is orchestrated by nine parasegment-specific regulatory domains. Autonomy of each domain is conferred by boundary elements (insulators). Here, we have used an in situ replacement strategy to reanalyze the sequences required for the functioning of one of the best-characterized fly boundaries, Fab-7. It was initially identified by a deletion, Fab-71, that...

Topics

Animals
Chromatin
Chromatin Immunoprecipitation
DNA Fragmentation
Drosophila
Drosophila Proteins
Epigenesis, Genetic
Gene Expression Regulation
Genes, Homeobox
Genes, Insect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulator Elements

Male

Mutation

Polycomb-Group Proteins

Response Elements

Source

Open in PubMed Open full text

Identifiers

PMID: 30110328
DOI: 10.1371/journal.pgen.1007442
PMCID: PMC6110506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.PMID 30110328Read ↗

In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element.Semantic proximity Read ↗

A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex.Semantic proximity Read ↗

The Fab-8 boundary defines the distal limit of the bithorax complex iab-7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain.Semantic proximity Read ↗

The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex.Semantic proximity Read ↗

The iab-7 polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activity.Semantic proximity Read ↗

Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex.Semantic proximity Read ↗

Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.Semantic proximity Read ↗

The Ubx Polycomb response element bypasses an unpaired Fab-8 insulator via cis transvection in Drosophila.Semantic proximity Read ↗

A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation.Semantic proximity Read ↗

Identification of a class of chromatin boundary elements.Semantic proximity Read ↗

Replacement of a Drosophila Polycomb response element core, and in situ analysis of its DNA motifs.Semantic proximity Read ↗

Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing.Semantic proximity Read ↗

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