Article
RNAi components are required for nuclear clustering of Polycomb group response elements.
Cell - 10 Mar 2006
Grimaud Charlotte, Bantignies Frédéric, Pal-Bhadra Manika, Ghana Pallavi, Bhadra Utpal, Cavalli Giacomo
Abstract excerpt
Drosophila Polycomb group (PcG) proteins silence homeotic genes through binding to Polycomb group response elements (PREs). Fab-7 is a PRE-containing regulatory element from the homeotic gene Abdominal-B. When present in multiple copies in the genome, Fab-7 can induce long-distance gene contacts that enhance PcG-dependent silencing. We show here that components of the RNA interference (RNAi) machinery are...
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