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Article

The Corfu deltabeta thalassemia deletion disrupts gamma-globin gene silencing and reveals post-transcriptional regulation of HbF expression.

Blood - 1 Mar 2005

Chakalova Lyubomira, Osborne Cameron S, Dai Yan-Feng, Goyenechea Beatriz, Metaxotou-Mavromati Anna, Kattamis Antonios, Kattamis Christos, Fraser Peter

Abstract excerpt

The 7.2 kilobase (kb) Corfu deltabeta thalassemia mutation is the smallest known deletion encompassing a region upstream of the human delta gene that has been suggested to account for the vastly different phenotypes in hereditary persistence of fetal hemoglobin (HPFH) versus beta thalassemia. Fet...

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Share to beta-Thalassemia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

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Source

Identifiers

PMID: 15536151
DOI: 10.1182/blood-2003-11-4069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15536151-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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