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Mechanism for fetal hemoglobin induction by hydroxyurea in sickle cell erythroid progenitors

1 Jan 2000

Abstract excerpt

Hydroxyurea (HU) is a widely used cytotoxic agent that is known to induce fetal hemoglobin (HbF) production and is presently used to ameliorate the severity of pain episodes in patients with sickle cell anemia (HbSS). Previously we have shown that HU inhibits growth of burst forming unit-erythroid (BFU-E) colonies in a dose-dependent manner, while fetal hemoglobin levels were increased. In the present report, we...

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PMID: 11074540
DOI: 10.1002/1096-8652(200011)65:3<227::aid-ajh9>3.0.co;2-v

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