Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allele-specific transcription of fetal genes in primary erythroid cell cultures from Lepore and deltabeta degrees thalassemia patients.

Experimental hematology - 1 Nov 2005

Di Marzo Rosalba, Acuto Santina, Calzolari Roberta, Maggio Aurelio

Abstract excerpt

OBJECTIVE: Autonomous gene silencing and gene competition by globin promoters for locus control region (LCR) function have been proposed as mechanisms in developmental regulation of beta-like genes. deltabeta degrees thalassemias are syndromes presenting an increased production of fetal hemoglobin in adult life; the majority of them are due to various deletions in beta-globin gene cluster. We studied samples from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythroid Cells
Share to Fetal Hemoglobin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Globins

Share to Hematopoietic Stem Cells

Share to In Situ Hybridization

Share to Thalassemia

Share to Transcription, Genetic

Source

Identifiers

PMID: 16263421
DOI: 10.1016/j.exphem.2005.07.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allele-specific transcription of fetal genes in primary erythroid cell cultures from Lepore and deltabeta degrees thalassemia patients.PMID 16263421Read ↗

Regulation of human fetal hemoglobin: new players, new complexitiesSemantic proximity Read ↗

Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expressionSemantic proximity Read ↗

A functional element necessary for fetal hemoglobin silencing.Semantic proximity Read ↗

Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies.Semantic proximity Read ↗

The Corfu deltabeta thalassemia deletion disrupts gamma-globin gene silencing and reveals post-transcriptional regulation of HbF expression.Semantic proximity Read ↗

Epigenetic regulation of fetal globin gene expression in adult erythroid cellsSemantic proximity Read ↗

Fetal hemoglobin silencing in humansSemantic proximity Read ↗

Chromatin Structure and Control of β-Like Globin Gene SwitchingSemantic proximity Read ↗

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunitiesSemantic proximity Read ↗

Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity.Semantic proximity Read ↗

Dominant influence of gamma-globin promoter polymorphisms on fetal haemoglobin expression in sickle cell disease.Semantic proximity Read ↗

Human fetal globin gene expression is regulated by LYARSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.