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Article

p53 associates with and targets ΔNp63 into a protein degradation pathway

13 Feb 2001

Abstract excerpt

A human p53 homologue, p63 (p40/p51/p73L/CUSP) that maps to the chromosomal region 3q27-29 was found to produce a variety of transcripts that encode DNA-binding proteins with and without a trans-activation domain (TA- or Delta N-, respectively). The p63 gene locus was found to be amplified in squamous cell carcinoma, and overexpression of Delta Np63 (p40) led to increased growth of transformed cells in vitro and...

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Identifiers

PMID: 11172034
DOI: 10.1073/pnas.98.4.1817

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