Article
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America - 13 Feb 2001
Haase V H, Glickman J N, Socolovsky M, Jaenisch R
Abstract excerpt
von Hippel-Lindau (VHL) disease is a pleomorphic familial tumor syndrome that is characterized by the development of highly vascularized tumors. Homozygous disruption of the VHL gene in mice results in embryonic lethality. To investigate VHL function in the adult we have generated a conditional VHL null allele (2-lox allele) and null allele (1-lox allele) by Cre-mediated recombination in embryonic stem cells. We...
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