Article
Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene.
Cancer research - 1 Sept 2003
Ma Wenbin, Tessarollo Lino, Hong Seung-Beom, Baba Masaya, Southon Eileen, Back Timothy C, Spence Sally, Lobe Corrinne G, Sharma Nirmala, Maher Gregory W, Pack Svetlana, Vortmeyer Alexander O, Guo Chuanfa, Zbar Berton, Schmidt Laura S
Abstract excerpt
von Hippel-Lindau (VHL) disease is a multisystem inherited cancer syndrome characterized by the development of highly vascular tumors including hemangioblastomas of the retina and central nervous system, pheochromocytomas, and clear cell renal carcinoma, which result from somatic inactivation of the wild-type VHL allele in cells harboring a germ-line VHL mutation. Homozygous inactivation of the VHL gene in mice...
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