Article

Disrupted astrocyte-endothelial crosstalk drives hemangioblastoma lesions in VHL disease

2025-09-18

Abstract excerpt

Hemangioblastomas (HBs) are highly vascularized central nervous system (CNS) tumours that can become life-threatening, especially in the context of Von Hippel-Lindau (VHL) disease, caused by the loss of VHL function. The limited pharmacological options targeting VHL-HBs stem from an incomplete understanding of their cellular origin, development, and molecular pathogenesis. Here we use advanced mouse genetics to sh...

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Literature Corpus work: f6e6df8c-8086-5e2c-8660-44f1535fb4aa
DOI: 10.1101/2025.09.15.675862

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