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Article

Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.

Molecular and cellular biology - 1 Jun 2005

Mack Fiona A, Patel Jagruti H, Biju Mangatt P, Haase Volker H, Simon M Celeste

Abstract excerpt

Inactivating mutations within the von Hippel-Lindau (VHL) tumor suppressor gene predispose patients to develop a variety of highly vascularized tumors. pVHL targets alpha subunits of the heterodimeric transcription factor hypoxia-inducible factor (HIF), a critical regulator of energy metabolism, angiogenesis, hematopoiesis, and oxygen (O(2)) delivery, for ubiquitin-mediated degradation in an O(2)-dependent...

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Share to Cyclin-Dependent Kinase Inhibitor p21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15899860
DOI: 10.1128/MCB.25.11.4565-4578.2005
PMCID: PMC1140627

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.PMID 15899860Read ↗

The VHL tumor suppressor and HIF: insights from genetic studies in mice.Semantic proximity Read ↗

Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.Semantic proximity Read ↗

The VHL tumor suppressor: master regulator of HIF.Semantic proximity Read ↗

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Ubiquitin Pathway in VHL Cancer SyndromeSemantic proximity Read ↗

The von Hippel-Lindau tumor suppressor gene.Semantic proximity Read ↗

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.Semantic proximity Read ↗

Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors.Semantic proximity Read ↗

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney CancerSemantic proximity Read ↗

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.Semantic proximity Read ↗

von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase.Semantic proximity Read ↗

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.Semantic proximity Read ↗

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