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Article

Shaker potassium channel mediates an age-sensitive neurocardiac axis regulating sleep and cardiac function in Drosophila.

Biogerontology - 18 Jan 2026

Madamanchi Kishore, Bannister Dalton, Docuyanan Ariel, Bhide Shruti, Melkani Girish C

Abstract excerpt

The Shaker (Sh) gene in Drosophila melanogaster encodes a voltage-gated potassium channel that regulates neuronal excitability and is well known for its role in sleep regulation; however, its contribution to cardiac physiology and neurocardiac communication remains insufficiently explored. In this study, we investigated how two Sh-mutations (Shmns and Sh5) influence heart function and sleep/circadian behaviors to...

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Identifiers

PMID: 41548155
DOI: 10.1007/s10522-026-10386-4
PMCID: PMC12812776

Genes

KCNA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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