Article
A negative regulatory role in mouse cardiac transplantation for a splice variant of CD80.
Transplantation - 27 Nov 2006
Bugeon Laurence, Wong Kenneth K, Rankin Alasdair M, Hargreaves Roseanna E G, Dallman Margaret J
Abstract excerpt
BACKGROUND: Members of the B7 costimulatory protein family (CD80 and CD86) play a determining role in allograft rejection. Both CD80 and CD86 have naturally occurring splice variants whose roles in transplantation are unknown. Full length CD80 has two immunoglobulin (Ig)-like domains in the extracellular portion, IgC and IgV. In mouse, the isoform IgV-CD80 lacks the IgC-like domain. Here we analyzed the role of...
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