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Article

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses

7 Mar 2011

Abstract excerpt

The immunoglobulin (Ig) superfamily consists of many critical immune regulators, including the B7 family ligands and receptors. In this study, we identify a novel and structurally distinct Ig superfamily inhibitory ligand, whose extracellular domain bears homology to the B7 family ligand PD-L1. This molecule is designated V-domain Ig suppressor of T cell activation (VISTA). VISTA is primarily expressed on...

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PMID: 21383057
DOI: 10.1084/jem.20100619

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