Germ line polymorphisms of the tumor suppressor gene p53 and lung cancer.

doi:10.1016/s0169-5002(00)00188-4

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Article

Germ line polymorphisms of the tumor suppressor gene p53 and lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Jan 2000

Biros E, Kalina I, Kohút A, Stubna J, Salagovic J

Abstract excerpt

Two p53 variable sites (BstUI and MspI SNPs in exon 4 and intron 6, respectively) and their haplotype combinations were studied in 109 patients (84 males and 25 females) with lung cancer and 113 healthy controls from the region of Eastern Slovakia. There were no differences found between lung cancer patients and controls carrying the distribution of p53 BstUI and MspI alleles. However, the genotype distribution...

Topics

Adult
Aged
DNA Damage
DNA, Neoplasm
Female
Genes, p53
Genetic Predisposition to Disease
Germ-Line Mutation
Haplotypes
Humans
Lung Neoplasms
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 11165394
DOI: 10.1016/s0169-5002(00)00188-4

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