Article
Association of p53 polymorphisms with breast cancer: a case-control study in Slovak population.
Neoplasma - 1 Jan 2007
Franeková M, Zúbor P, Stanclová A, Dussan C A, Bohusová T, Galo S, Dobrota D, Kajo K, Péc M, Racay P
Abstract excerpt
Protein p53 is the tumor suppressor involved in cell cycle control and apoptosis. As a transcription factor p53 controls many cell processes and helps in prevention of cancer development. The p53 gene is polymorphic. Polymorphisms can affect the important regions involved in protein tumor suppressor activity. The well-known polymorphisms are the polymorphisms BstUI in exon 4 and MspI in intron 6. Both are...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Breast Neoplasms
- Case-Control Studies
- DNA, Neoplasm
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Female
- Genotype