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Article

A test of translational selection at 'silent' sites in the human genome: base composition comparisons in alternatively spliced genes.

Gene - 30 Dec 2000

Iida K, Akashi H

Abstract excerpt

Natural selection appears to discriminate among synonymous codons to enhance translational efficiency in a wide range of prokaryotes and eukaryotes. Codon bias is strongly related to gene expression levels in these species. In addition, between-gene variation in silent DNA divergence is inversely correlated with codon bias. However, in mammals, between-gene comparisons are complicated by distinctive...

Topics

Alternative Splicing
Animals
Base Composition
Codon
CpG Islands
Databases, Factual
Drosophila melanogaster
Gene Expression Regulation
Genes
Genetic Variation
Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Protein Biosynthesis

Selection, Genetic

Source

Identifiers

PMID: 11164041
DOI: 10.1016/s0378-1119(00)00482-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11164041-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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