Article
Allele-specific histone acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene.
Endocrinology - 1 Dec 2000
Hu J F, Pham J, Dey I, Li T, Vu T H, Hoffman A R
Abstract excerpt
The mouse insulin-like growth factor II receptor (Igf2r) gene encodes two reciprocally imprinted RNA transcripts: paternally imprinted Igf2r sense and maternally imprinted Igf2r antisense. Although DNA methylation has been implicated in the initiation and maintenance of genomic imprinting, acetylation of core histones has recently been appreciated as another important factor that regulates gene expression. To...
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