Article
Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.
Genes & development - 1 Oct 1992
Sasaki H, Jones P A, Chaillet J R, Ferguson-Smith A C, Barton S C, Reik W, Surani M A
Abstract excerpt
The mouse insulin-like growth factor II (Igf2) gene, which is located on distal chromosome 7 (Chr7), has been shown previously to undergo tissue-specific parental imprinting. This imprinting results in expression of Igf2 from the paternally inherited chromosome and repression of the maternally inherited allele in most tissues of the developing embryo. We are using embryos with the maternal duplication and...
Topics
- Alleles
- Animals
- Base Sequence
- Cells, Cultured
- Chromatin
- DNA
- Deoxyribonuclease HpaII
- Deoxyribonuclease I
- Deoxyribonucleases, Type II Site-Specific
- Female
- Gene Expression Regulation